논문업데이트

Home. 최근뉴스. 논문업데이트

논문업데이트

Bronchial inflammation in seasonal allergic rhinitis with or without a…

페이지 정보

작성자 관리자
댓글 0건 조회 1,620회 작성일 15-02-04 16:08

본문

Allergol Immunopathol (Madr). 2015 Jan-Feb;43(1):3-9. doi: 10.1016/j.aller.2013.06.009. Epub 2013 Sep 25.

Bronchial inflammation in seasonal allergic rhinitis with or without asthma in relation to natural exposure to pollen allergens.

Panzner P1, Malkusová I2, Vachová M2, Liška M2, Brodská P3, Růžičková O4, Malý M5.

Author information

  • 1Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University Prague, Czech Republic. Electronic address: panzner@fnplzen.cz.
  • 2Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University Prague, Czech Republic.
  • 3Department of Dermatology, Faculty of Medicine in Pilsen, Charles University Prague, Czech Republic.
  • 4Department of Respiratory Medicine, Faculty of Medicine in Pilsen, Charles University Prague, Czech Republic.
  • 5National Institute of Public Health, Prague, Czech Republic.

Abstract

BACKGROUND:

Nasal inflammation in allergic rhinitis enhances bronchial Th2 driven inflammation and development of asthma. We assessed bronchial inflammation induced by natural allergen exposure during pollen season in patients with pollinosis with or without asthma to show the intensity of inflammation in asthma and rhinitis and possible persistence of inflammation in periods without allergen exposure.

METHODS:

Sputum was induced in 52 patients with seasonal allergic rhinitis without asthma, 38 patients with seasonal allergic rhinitis and seasonal asthma and 23 healthy volunteers. Sampling was performed 6-8 weeks before the expected beginning of symptoms, during symptomatic period and 6-8 weeks after the end of symptoms. Sputum ECP was measured by means of chemiluminiscent immunometric assay and sputum cell counts were assessed by classical staining and immunocytochemistry.

RESULTS:

Sputum eosinophils were on the whole higher in both asthma and rhinitis compared to controls (p<0.001, p=0.003). The rise of eosinophils during pollen season compared with values out of pollen season was significant in asthma (classical staining) (p=0.014) and slightly apparent in rhinitis (immunocytochemistry) (p=0.073). The seasonal rise of sputum ECP was observed only in rhinitis (p=0.006).

CONCLUSIONS:

Inflammation of the lower airway in patients with allergic rhinitis with and without asthma has been confirmed by means of both sputum eosinophil count and sputum ECP level. Persistent inflammation of lower airway in periods without allergen exposure was proven in seasonal asthma. This may have implications for the therapy of seasonal allergic rhinitis with and without asthma in terms of promoting long-term anti-inflammatory treatment.
Copyright © 2013 SEICAP. Published by Elsevier Espana. All rights reserved.

KEYWORDS:

Allergic rhinitis; Asthma; Induced sputum; Pollen allergy
  • 목록

    • 댓글목록

    등록된 댓글이 없습니다.