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Pollen-derived adenosine is a necessary co-factor for ragweed allergy.

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Allergy. 2015 May 2. doi: 10.1111/all.12642.
 

Pollen-derived adenosine is a necessary co-factor for ragweed allergy.

Wimmer M1, Alessandrini F, Gilles S, Frank U, Oeder S, Hauser M, Ring J, Ferreira F, Ernst D, Barbro Winkler J, Schmitt-Kopplin P, Ohnmacht C, Behrendt H, Schmidt-Weber C, Traidl-Hoffmann C, Gutermuth J.
 

Abstract

BACKGROUND :Ragweed (Ambrosia artemisiifolia) is a strong elicitor of allergic airway inflammation with worldwide increasing prevalence. Various components of ragweed pollen are thought to play a role in the development of allergic responses. Aim of the study was to identify critical factors for allergenicity of ragweed pollen in a physiologic model of allergic airway inflammation
METHODS: Aqueous ragweed pollen extract, the low molecular weight fraction or the major allergen Amb a 1 were instilled intranasally on 1 - 11 consecutive days and allergic airway inflammation was evaluated by bronchoalveolar lavage, lung histology, serology, gene-expression in lung tissue and measurement of lung function. Pollen-derived adenosine was removed from the extract enzymatically in order to analyze its role in ragweed-induced allergy. Migration of human neutrophils and eosinophils towards supernatants of ragweed-stimulated bronchial epithelial cells was analyzed
RESULTS: Instillation of ragweed pollen extract, but not of the major allergen or the low molecular weight fraction, induced specific IgG1 , pulmonary infiltration with inflammatory cells, a Th2-associated cytokine signature in pulmonary tissue and impaired lung function. Adenosine aggravated ragweed-induced allergic lung inflammation. In vitro, human neutrophils and eosinophils migrated towards supernatants of bronchial epithelial cells stimulated with ragweed extract only if adenosine was present
CONCLUSIONS: Pollen-derived adenosine is a critical factor in ragweed-pollen induced allergic airway inflammation. Future studies aim at therapeutic strategies to control these allergen-independent pathways This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
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