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J Pharmacol Exp Ther. 2016 Mar 4. pii: jpet.115.229799. [Epub ahead of print]

Role of prostaglandin D2 and DP1 receptor on Japanese cedar pollen-induced allergic rhinitis in mice.

Nakano Y¹, Kidani Y¹, Goto K¹, Furue S¹, Tomita Y¹, Inagaki N², Tanaka H², Shichijo M³.

Abstract

Although we previously demonstrated the contribution of the DP₁ receptor in nasal obstruction using animals sensitized with ovalbumin in the presence of adjuvant, the contribution of the DP₁ receptor in sneezing is unclear. Here, we developed a mouse model of Japanese cedar (JC: Cryptomeria Japonica) pollinosis to evaluate the symptoms of sneezing. To achieve this, we used JC pollen crude extract in the absence of adjuvant to sensitize mice to develop a model to closer to the pathophysiology of human JC pollinosis. The immunological and pharmacological features of this model are highly similar to those observed in JC pollinosis in humans. Using this model we found that DP₁ receptor antagonists suppressed JC pollen extract-induced sneezing, and that a DP₁ receptor agonist induced sneezing. Moreover, JC pollen extract-induced sneezing was diminished in DP₁ receptor KO mice. In conclusion, we developed a novel mouse model of allergic rhinitis that closely mimics human JC pollinosis. A strong contribution of DP₁ receptor signaling to sneezing was demonstrated using this model, suggesting that DP₁ receptor antagonists could suppress sneezing as well as nasal obstruction, and therefore they could be a new therapeutic option for allergic rhinitis.