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Peculiarities of phenotyping of lymphocytes in patients with pollen al…

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Peculiarities of phenotyping of lymphocytes in patients with pollen allergy against the backdrop of active herpesvirus infection type 4, 5 and 6<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

Chopyak, Valentyna; Zubchenko, Svitlana; Yuriev, Sergey; Gubska, Olena.

(Journal of Allergy and Clinical Immunology, suppl. S; St. Louis Vol. 141, Iss. 2,  (Feb 1, 2018): AB230. DOI:10.1016/j.jaci.2017.12.7)
 
Rationale

 

Study the peculiarities of the phenotypic characteristics of lymphocytes and their activation markers in patients with pollen allergy against herpesvirus infections.

 

Methods

162 persons were examined with clinical and laboratory manifestations of pollen allergy, age 32,6 ± 2,4 years, 53,1% - women, 46,9% - men. SPT Diater, Spain, total and specific IgE, ELISA. EBV, CMV, HHV6 by the polymerase chain reaction using Rotor Geen 6000. Phenotyping of lymphocytes - a flow cytofluorimetre “Bekton Dickenson” (USA).

 

Results

 

Based on specific allergic studies, pollen allergy was confirmed in 158 (97.5%) patients, in 112 (70.8%) of whom polysensitization was detected, and in 46 (29.2%) monosensitization was confirmed. According to the data of molecular genetic studies, in 128 (81.0%) cases activated herpesvirus infection was detected: in 48 (37.5%) cases - monoinfection, in 80 (62.5%) - combined infection and in most 47 (58.7%) cases EBV + HHV6. Patients were divided into 3 groups: the first one - people with pollen allergy without viral activity; the second one - people with pollen allergy + viral activity. Third group - 50 healthy people. Patients in the second group showed an increase in CDHLA-DR + cells and B-lymphocytes and decreased NK-cells (p<0.05). In 75.0% of these patients, increases of levels of total IgE, that was 1.1 times more than in patients in the first group.

 
Conclusions

 

In patients with pollen allergy against the backdrop of active herpesvirus infection, there was an increase in the cell-dependent inflammatory process with the creation of conditions for the formation of hyper-IgE syndrome.

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