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Safety and effect on reported symptoms of depigmented-polymerised alle…

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Pediatr Allergy Immunol. 2015 Jan 30. doi: 10.1111/pai.12347. [Epub ahead of print]

Safety and effect on reported symptoms of depigmented-polymerised allergen immunotherapy: a retrospective study of 2927 paediatric patients.

Pfaar O1, Sager A, Robinson DS.

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  • 1Center for Rhinology and Allergology, Dept. of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany.

Abstract

BACKGROUND:

Allergen immunotherapy (AIT) is effective treatment for allergic diseases, and subcutaneous use of depigmented-polymerised extracts may allow rapid up-dosing and safe therapy. To date, there is little information on their safety and clinical effects for children and adolescents with allergic disease.

METHODS:

We performed a retrospective survey of patient notes of 2927 children and adolescents across 136 centres who had received AIT with depigmented-polymerised extracts to pollen or mite allergens for at least one year to collect documentation on safety and clinical symptoms.

RESULTS:

38% of patients had local reactions, of these 145 were larger than 12 cm in diameter. Systemic reactions were documented in 2.7% of children and 1.2% of adolescents. There were no documented cases of anaphylactic shock. There were significant reductions in the frequency of patients with recorded nasal symptoms over time of treatment. Moreover, the prescribing-rate of rescue medication was reduced over the course of SCIT.

CONCLUSION:

These 'real-life'-data from a large retrospective analysis including 2927 children and adolescents with pollen and/or mite induced allergic rhinoconjunctivitis with/or without allergic asthma indicate that AIT with depigmented-polymerised extracts is well tolerated are compatible with clinical response. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.

KEYWORDS:

allergen; allergen immunotherapy (AIT); allergic rhinoconjunctivitis; depigmented-polymerised; non-interventional study (NIS); real-life-data
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