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Adverse reactions to immunotherapy are associated to different pattern…

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Allergy. 2015 Jan 29. doi: 10.1111/all.12575. [Epub ahead of print]

Adverse reactions to immunotherapy are associated to different pattern of sensitization to grass allergens.

Sastre J1, Rodríguez F, Campo P, Laffond E, Marín A, Alonso MD.

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  • 1Fundación Jimenez Díaz.

Abstract

The aim of the study was to investigate if adverse drug reactions (ADRs) during immunotherapy with a grass extract (AVANZ® Phleum, ALK-Abelló) are related to the different patterns of sensitization of patients to grass allergens. 192 patients with rhinitis and/or asthma sensitized to grass pollen received a 4-week up-dosing with 5-injections. ADRs were evaluated following EAACI guidelines. A total of 432 ADRs in 133 (69%) patients were recorded, 64% local and 31% systemic. There was a significant association of the number of grass allergens sensitized by the patients and the total number of ADRs (p=0.004) occurred locally (p=0.003) and systemically (p=0.01) Sensitization to Phl p1+ Phl p5 or Phl p1+ Phl p5+ Phl p12 was significantly associated with a higher frequency of local or systemic reactions (p=0.001,both). Different patterns of sensitization to grass allergens may potentially be considered a risk marker to the development of ADRs to immunotherapy. This article is protected by copyright. All rights reserved.
 

KEYWORDS:

grass allergens; immunotherapy; molecular diagnosis; safety
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